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Listen a mother and her daughter on the phone. The mother is asking her daughter to go to the chemist's and buy some painkillers.

British English

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I'm out of painkillers
Meaning The painkillers are finished.
Examples We need to go shopping, because we're out of bread.
Particle Out sometimes means that something is finished. The verb run out is very similar: I've run out of painkillers would be the same.

 

Could you pick some up?
Meaning She's asking her daughter to buy some painkillers.
Examples Keys must be picked up and returned to the Area Office during regular office hours.
Particle Up means preparing, starting, creating.

 

You could drop them off
Meaning Stop at her mother's and give her the keys
Examples Did you drop the keys off with Mel?
Particle Off means departure. Letting something go.

 

I'll try and pop in
Meaning Pay a short visit
Examples I only popped in to say hello.
Particle In means come into the house.